Crystal structure of a plasma membrane proton pump
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United States of America Patent
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Nov 5, 2013
Grant Date -
Nov 25, 2010
app pub date -
Dec 12, 2008
filing date -
Dec 12, 2007
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Abstract
The present invention relates to a crystal structure of a plasma membrane proton pump type ATPase. The invention further describes method for identification of modulators of ATPases as well as uses of such modulators. Based on the provided three dimensional structure of the ATPase, various method, such as computer implemented methods may be used for identification of modulators, such putative modulators may be further analysed using in vitro and in vivo experiments to confirm there functionality. Several modulator interaction regions are described as target of regulation by ATPase modulators.
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