Synthetic method for montelukast sodium intermediate
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United States of America Patent
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Oct 29, 2013
Grant Date -
Jun 28, 2012
app pub date -
Aug 24, 2010
filing date -
Sep 2, 2009
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Abstract
A synthesis method for preparing Montelukast sodium intermediate 2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl) propanol is provided. In this method, the target compound is prepared by condensing the starting materials 7-chloroquinaldine and 3-cyanobenzaldehyde, and then reacting the resultant product with 2-(2-ortho-(2-haloethyl)-phenylpropyl)tetrahydropyrane ether. The present invention can easily obtain start materials and is applicable for mass production.
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