Engineered pertactin variants for vaccine use
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United States of America Patent
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Oct 29, 2013
Grant Date -
Mar 24, 2011
app pub date -
Oct 17, 2008
filing date -
Oct 30, 2007
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Abstract
The present invention is related with the field of Biomedicine. It comprises the engineering of the Pertactin protein (Prn) and using it as part of bacterial vaccines, and more precisely, as part of acellular vaccines against Bordetella pertusis. The engineered Prn molecules comprise on their structure polimorfisms from different B. pertussis strains, and induce immune responses with protective capacity and opsonophagocytic activity when assayed as vaccines, higher than that generated by other pre-existing vaccines. The engineered Prn variants of the present invention are applicable in human and veterinary medicine.
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