4′-demethylepipodophyllotoxin derivative, preparation method and use thereof
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United States of America Patent
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Oct 29, 2013
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Feb 14, 2013
app pub date -
Apr 22, 2011
filing date -
Apr 23, 2010
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Abstract
A 4′-demethylepipodophyllotoxin derivative of formula(III) having anti-tumor activity is provided. After the activation of hydroxyl in position C4 of 4′-demethylepipodophyllotoxin, tetramethylpyrazine is introduced by transamination to obtain the 4′-demethylepipodophyllotoxin derivative which is preferably used to inhibit gastric cancer line BGC-823.
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