Morphinan derivatives and preparation methods thereof
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United States of America Patent
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Oct 22, 2013
Grant Date -
May 12, 2011
app pub date -
Jun 19, 2009
filing date -
Jun 20, 2008
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Abstract
The present invention relates to morphinan derivatives and preparation methods thereof, especially to ketal hydroxyl protected compounds of morphinan derivatives and preparation method thereof, and to a method for preparing corresponding alkylated morphinan derivatives by using the ketal hydroxyl protected compounds as intermediates, and more especially to a ketal hydroxyl protected compound of methylnaltrexone as intermediate for preparing methylnaltrexone and a method for preparing methylnaltrexone through said intermediate.
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