Modified oligonucleotide and its preparation and application

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United States of America Patent

PATENT NO 8563710
APP PUB NO 20120088815A1
SERIAL NO

13262702

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Abstract

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The present invention relates to a modified oligonucleotide, its preparation and application. The invention eables stabilizing the oligonucleotide by introducing a relatively small amount of modified nucleotide at specific UA/UA and/or CA/UG and/or UG/CA site of the oligonucleotide, therefore to decrease the modification-related cytotoxicity and compromising effects on the biological activity.

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Patent Owner(s)

Patent OwnerAddress
BIOMICS BIOTECHNOLOGIES CO LTD226016 JIANGSU CITY OF NANTONG PROVINCE ECONOMIC AND TECHNOLOGICAL DEVELOPMENT ZONE NO 76 CHANG XING LU NANTONG CITY JIANGSU PROVINCE 226016

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liang, Zicai Beijing, CN 16 97

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