Camptothecin derivatives as chemoradiosensitizing agents
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United States of America Patent
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Oct 22, 2013
Grant Date -
Dec 25, 2008
app pub date -
Jul 29, 2008
filing date -
Oct 21, 2005
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Abstract
Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.
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