Stable digestive enzyme compositions
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United States of America Patent
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Oct 22, 2013
Grant Date -
May 26, 2011
app pub date -
Feb 2, 2011
filing date -
Feb 20, 2007
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Abstract
Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.
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