Importance

Loading Importance Indicators...

Abstract

Compounds of formula (I) are inhibitors of p38 MAP kinase, useful as anti-inflammatory agents in the treatment of inter alia, diseases of the respiratory tract wherein; R¹ is C₁-C₆ alkyl, C₃-C₆ cycloalkyl, phenyl which is optionally substituted, 5- or 6 membered monocyclic heteroaryl which is optionally substituted, or a radical of formula (II) wherein n is 1 or 2, and R³ and R⁴ are independently H or C₁-C₆ alkyl, or R³ and R⁴ taken together with the nitrogen to which they are attached form a 6-membered heterocyclic ring optionally containing a further heteroatom selected from N and O; Y is —O— or —S(O)_p— wherein p is 0, 1 or 2; A is an optionally substituted divalent arylene radical, or a mono- or bicyclic heteroarylene radical, or a C₃-C₆ divalent cycloalkylene radical having 5 or 6 ring atoms, or a piperidinylene radical wherein the ring nitrogen is linked to R²NHC(═O)W—; W is a bond, —NH— or —C(R^A)(R^B), wherein R^A and R^B are independently H, methyl, ethyl, amino, hydroxyl or halo; and R² is a radical as defined in the claims.

Loading the Abstract Image...

First Claim