Homodimer of insulinotropic peptide analogues and method for preparation thereof and use thereof
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United States of America Patent
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Oct 15, 2013
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Nov 1, 2012
app pub date -
Mar 15, 2010
filing date -
Aug 20, 2009
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Abstract
Provided is a homodimer of insulinotropic peptide analogues and method for preparation thereof and use thereof, wherein the insulinotropic peptide analogue comprises GLP-1 and Exendin-4. The homodimer of insulinotropic peptide analogues of the invention is made by conjugating two identical insulinotropic peptide analogue molecules at the C-terminal Cys residues via disulfide bond or PEG molecule. The homodimer of insulinotropic peptide analogues of the invention has superior stability and biological activity in vivo, and prolonged half-life in the circulation, and can be used for the preparation of hypoglycemic drugs.
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