Bifunctional glycoproteins having a modified carbohydrate complement and their use in tumor-selective therapy
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United States of America Patent
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Oct 8, 2013
Grant Date -
Oct 14, 2004
app pub date -
Apr 2, 2004
filing date -
May 4, 1993
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Abstract
Provided herein are carbohydrate complement-modified bifunctional glycoproteins, and their use in tumor-selective therapy. The bifunctional glycoproteins comprise a first component that specifically binds to a tumor-specific antigen and a second component having enzymatic activity by means of which a non-toxic prodrug is cleaved into a cytotoxic drug. The carbohydrate complement comprises at least one exposed carbohydrate residue selected from the group consisting of mannose, galactose, N-acetylglucosamine, N-acetyllactose, glucose and fucose. The modified carbohydrate complement contributes to increased relative concentration of the glycoproteins at the site of the tumor, and enhanced clearance from the general circulation and non-tumor sites.
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