Efficient and universal method for neural differentiation of human pluripotent stem cells
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United States of America Patent
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Oct 8, 2013
Grant Date -
Sep 8, 2011
app pub date -
Aug 31, 2010
filing date -
Nov 6, 2009
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Abstract
The present invention relates to a method for inducing neural differentiation of stem cells. In more detail, the present invention relates to a method for inducing neural differentiation of stem cells by inhibiting both BMP (bone morphogenetic protein) and Activin/Nodal signaling pathways in the stem cells. The present invention allows all types of stem cells to effectively differentiate into neural precursor cells regardless of conventional methods for stem cell differentiation including floating culture and attachment culture. In addition, since the neural precursor cells induced by the present invention may be differentiated into specific cells (e.g., dopaminergic neurons) or oligodendrocytes in higher efficient manner, they may be applied to treatment of incurable nerve diseases (e.g., Parkinson's disease or spinal cordinjury) and further provide fundamental data on new drug development.
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