Polymer conjugates of Box-A of HMGB1 and Box-A variants of HMGB1

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United States of America Patent

PATENT NO 8546547
SERIAL NO

12441478

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Abstract

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The present invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or of a biologically active fragment of HMGB1 Box-A. Further, the invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A). Moreover, the present invention concerns the use of said polymer conjugates of polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and/or associated with an increased expression of RAGE.

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CREABILIS THERAPEUTICS S P ABIOINDUSTRY PARK VIA RIBES 5 10010 COLLERETTO GIACOSA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beccaria, Luca Ivrea, IT 5 59
Fumero, Silvano Ivrea, IT 8 77
Lorenzetto, Chiara Villafranca Plemonte, IT 7 73
Mainero, Valentina Ivrea, IT 11 67
Morena, Sebastiano Chivasso, IT 3 3
Traversa, Silvio Palazzo Canavese, IT 10 67

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