Isotopically enriched pyrimidin-5-yl acetic acid derivatives as CRTH2 antagonists
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United States of America Patent
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Sep 24, 2013
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Jul 14, 2011
app pub date -
Sep 1, 2009
filing date -
Sep 2, 2008
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Abstract
Provided herein are 2H- and 13C-enriched compounds of formula (I) or (II); wherein R is as defined herein, and wherein at least one hydrogen atom, in certain embodiments, three or more hydrogen atoms, are deuterium atoms or at least one carbon atom is a carbon-13 atom. Also provided are pharmaceutical compositions and methods using the 2H- and 13C-enriched compounds, useful for treating CRTH2-related diseases or disorders such as, for example, asthma, allergic rhinitis, atopic dermatitis, allergic conjuvatitis, Churg-Strauss syndrome, sinusitis, basophilic leukemia, chronic urticaria or basophilic leukocytosis.
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