Method of preparing nano-dispersed high-all-trans-carotenoid microcapsules

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United States of America Patent

PATENT NO 8540908
APP PUB NO 20120018912A1
SERIAL NO

13259291

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Abstract

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A method of preparing nano-dispersed high-all-trans-carotenoid microcapsules is provided, comprising: preparing 10-20% carotenoid suspension by milling the high-all trans-carotenoid crystals with dichloromethane until the particle size thereof is in the range of 2-5 μm, then supplying the suspension together with preheated dichloromethane of another pass into a dissolving tank to obtain a solution of 0.5-2%; delivering the solution together with ethanol or isopropanol into a crystallization device having high gravity rotating packed bed simultaneously and continuously, and then into a wiped-film evaporator for desolvation until the solid content is 10-20%, then a transparent alcohol dispersion of carotenoid is obtained; mashing the alcohol dispersion together with an aqueous solution containing an antioxidant and protective colloid and spray drying to obtain nano-dispersed high-all-trans-carotenoid microcapsules. As the crystals are nano-dispersed and the content of trans-isomer is more than 90%, the carotenoid microcapsules of present inventions exhibit high bioavailability.

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Patent Owner(s)

Patent OwnerAddress
BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY100029 NO 15 EAST THIRD RING ROAD CHAOYANG DISTRICT BEIJING MUNICIPAL DISTRICT BEIJING CITY 100029
ZHEJIANG UNIVERSITY310027 NO 38 ZHEJIANG ROAD ZHEJIANG HANGZHOU HANGZHOU CITY ZHEJIANG PROVINCE 310027
ZHEJIANG NHU COMPANY LTDSHAOXING ZHEJIANG 312500

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Jianfeng Beijing, CN 122 682
Chen, Zhirong Hangzhou, CN 42 118
Chu, Guangwen Beijing, CN 15 64
Li, Jiandong Shaoxing, CN 17 30
Qiu, Dan Hangzhou, CN 20 282
Shao, Lei Beijing, CN 42 993
Shi, Lifang Shaoxing, CN 13 34
Yin, Hong Hangzhou, CN 25 56
Zhao, Hong Beijing, CN 291 4048

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