β-hydroxy-γ-aminophosphonates and methods for the preparation and use thereof

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United States of America Patent

PATENT NO 8536362
APP PUB NO 20130079308A1
SERIAL NO

13427155

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Abstract

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The present invention provides β-hydroxy-γ-aminophosphonates, β-amino-γ-aminophosphonates, and analogs thereof that inhibit carnitine acyltransferases. The invention also provides compositions comprising these β-hydroxy-γ-aminophosphonates, β-amino-γ-aminophosphonates, and analogs, and methods of the use of such compounds and compositions in the treatment, amelioration or prevention of pathological conditions, diseases or disorders that are linked with fatty acid metabolism, such as non-insulin dependent diabetes or obesity. The invention also provides processes for the preparation of such compounds and compositions.

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NUCITEC S A DE C VQUERETARO QRO 76180

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, La Cruz Cordero Ricardo Abraham Huixtla Chis, MX 3 3
Loria, Jorge Luis Rosado Querétaro, MX 2 3
Vázquez, Miguel Ångel Duarte Guanajuato, MX 1 1

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