Inhibitors of AKT activity
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United States of America Patent
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Sep 17, 2013
Grant Date -
Apr 7, 2011
app pub date -
May 27, 2009
filing date -
Jun 3, 2008
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Abstract
The instant invention provides for substituted [1,2,4]triazolo[4,3-a]-1,5-naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms, preferably Akt1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity, especially Akt1 by administering the compound to a patient in need of treatment of cancer.
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