Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
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United States of America Patent
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Sep 17, 2013
Grant Date -
Nov 5, 2009
app pub date -
Apr 11, 2007
filing date -
Apr 13, 2006
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Abstract
Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
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