Structuring hydrogels
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United States of America Patent
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Sep 17, 2013
Grant Date -
Dec 13, 2007
app pub date -
May 23, 2007
filing date -
Jun 8, 2006
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Abstract
The present invention relates to a method for the preparation of a surface structured bulk hydrogel bearing a topographic and chemical pattern, comprising the steps of:
- (i) providing a primary master having a predetermined topographic pattern,(ii) replicating said primary master by an elastomeric secondary master to obtain a secondary master with said predetermined topographic pattern in its inverse form,(iii) replicating said secondary master by an imprintable curable material of hydrogel precursor molecules which are capable of forming a hydrogel once crosslinked by curing, and crosslinking said material to thereby yield a replica made of cross-linked bulk hydrogel bearing the topographic pattern identical to that of the primary master, and(iv) functionalizing, particularly biofunctionalizing, the bulk hydrogel replica.
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