Methods and materials for producing transgenic artiodactyls
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United States of America Patent
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Aug 27, 2013
Grant Date -
Aug 30, 2012
app pub date -
May 9, 2012
filing date -
Feb 11, 2010
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Abstract
Swine animal models comprising a genomic disruption of an endogenous gene chosen from the group consisting of a Low-Density Lipoprotein Receptor gene LDLR, Duchene's Muscular Dystrophy (DMD) gene, and hairless gene (HR). Methods of preparing transfected cells useful for making a transgenic animal comprising exposing a first group of cells to a transfection agent and reseeding the group with additional cells that have not been exposed to the agent. The transgenic animals are useful for medical and scientific animal models of human diseases and conditions, as well as sources for cells, tissues, and biomaterials.
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