Methods for genetic diversification in gene conversion active cells
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United States of America Patent
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Aug 27, 2013
Grant Date -
Aug 9, 2007
app pub date -
Feb 23, 2005
filing date -
Feb 23, 2004
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Abstract
The invention relates to a modified lymphoid cell having gene conversion fully or partially replaced by hypermutation, wherein said cell has no deleterious mutations in genes encoding paralogues and analogues of the RAD51 protein, and wherein said cell is capable of directed and selective genetic diversification of a target nucleic acid by hypermutation or a combination of hypermutation and gene conversion. The invention also relates to a method for diversifying any transgenic target gene in said cell. Preferably, the target gene is integrated into the immunoglobulin light or heavy chain locus by targeted integration.
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