Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
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United States of America Patent
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Aug 27, 2013
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Apr 14, 2011
app pub date -
Nov 29, 2010
filing date -
Oct 27, 2006
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Abstract
The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.
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