Fish cancer model
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United States of America Patent
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Aug 20, 2013
Grant Date -
Oct 25, 2012
app pub date -
Jun 26, 2012
filing date -
Jul 19, 2005
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Abstract
The present invention is directed to fish whose genome has integrated therein an oncogenic nucleic acid operably linked to a promoter. Methods of making the fish and methods for their use are also provided. The fish may advantageously be utilized in methods of screening for drugs or agents that modulate oncogene-mediated neoplastic or hyperplasic transformation, or that modulate sensitivity to chemotherapy or radiation therapy. Immortal tumor cells lines, methods of making immortal tumor cells lines and methods of their use are also provided.
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