Process for the manufacture of oligonucleotides
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United States of America Patent
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Aug 20, 2013
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Apr 14, 2011
app pub date -
Apr 24, 2009
filing date -
Apr 24, 2008
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Abstract
A process for manufacturing an oligonucleotide which comprises removing β-eliminating phosphorus-protecting groups, in particular β-cyanoethyl protective groups from a protected oligonucleotide, wherein said removing comprises contacting the protected oligonucleotide with an amine solution in a solvent which preferably does not consist of pyridine, wherein the conjugate acid of the amine has preferably a pKa of greater than 11.5, and wherein the concentration of the amine in the solution is less than 0.5 mole/liters.
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