Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase

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United States of America Patent

PATENT NO 8512972
APP PUB NO 20120282627A1
SERIAL NO

13230548

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Abstract

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The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate EGLN1 prolyl hydroxylase and thereby regulate HIF-regulated disorders.

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Patent Owner(s)

Patent OwnerAddress
AKEBIA THERAPEUTICS INC245 FIRST STREET SUITE 1400 CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boyer, Angelique Sun West Chester, US 18 488
Evdokimov, Artem Gennady Loveland, US 7 327
Kawamoto, Richard Masaru Lebanon, US 22 586
Mekel, Marlene Jan Ross, US 5 155
Pokross, Matthew Eugene Hamilton, US 7 323
Walter,, Jr Richard Lee Hamilton, US 3 117

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