Biphenylcarboxamide derivatives as hedgehod pathway modulators
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United States of America Patent
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Aug 13, 2013
Grant Date -
Aug 5, 2010
app pub date -
Jun 4, 2008
filing date -
Jun 7, 2007
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Abstract
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
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