Culturing cells in a compartmentalized roller bottle

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United States of America Patent

PATENT NO 8501468
APP PUB NO 20110212519A1
SERIAL NO

12715191

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Abstract

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A versatile compartmentalized cell culture device, with a selectively permeable membrane separating the compartments, provides many attributes relative to traditional devices. It can be configured for high-density cell culture, co-culture, and sample dialysis while rolling or standing still. It can also be configured for continuous movement of liquid between compartments. The wide combination of attributes not found in other membrane based cell culture and bioprocessing devices includes more cell capacity, more cell secreted product capacity, higher cell and product density, increased medium capacity, minimized use of exogenous growth factors, compatibility with standard cell culture equipment and protocols, increased scale up efficiency, capacity to function when rolling or standing still, capacity for perfusion without the need for pumps, and more efficient sample dialysis.

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Patent Owner(s)

Patent OwnerAddress
WHEATON INDUSTRIES INC1501 NORTH 10TH STREET MILLVILLE NJ 08332

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Page, Douglas A Bloomington, US 19 699
Robeck, Alison St. Michael, US 11 579
Welch, Daniel P Zimmerman, US 22 827
Wilson, John R New Brighton, US 170 9289

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