Nitrilases and methods for making and using them
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United States of America Patent
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Aug 6, 2013
Grant Date -
Jan 12, 2012
app pub date -
Sep 21, 2011
filing date -
Dec 29, 1999
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Abstract
The invention provides nitrilases and methods for making and using them, and in one aspect, provides methods for producing enantiomerically pure α-substituted carboxylic acids, such as, for example, α-amino acids and α-hydroxy acids. In one aspect, methods of the invention combine an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity, to stereoselectively hydrolyze the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.
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