Method for producing a crystalline tableting additive, additive thus obtained and use thereof
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United States of America Patent
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Aug 6, 2013
Grant Date -
Aug 30, 2012
app pub date -
Feb 29, 2012
filing date -
Jul 20, 2000
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Abstract
A method for producing a tableting additive, which method comprises providing a spray dried tableting additive in particulate form which particles at leas partially consist of amorphous additive material and at least partially of crystalline additive material; and crystallising the amorphous additive material by subjecting the particles for a short time and under agitation to a temperature between 30 and 100° C. at a relative humidity between 60 and 25%. More in particular, the relationship between relative humidity and temperature is defined by the formula: % relative humidity=218-47*Ln(T(° C.)), wherein T(° C.) is the temperature to which the particles are subjected.
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