Antibodies to high mobility group-1(HMGB1) B-box polypeptides
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United States of America Patent
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Aug 6, 2013
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N/A
app pub date -
Jan 11, 2011
filing date -
May 15, 2001
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Expired
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Abstract
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation that specifically binds to a vertebrate HMGB B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.
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