Evolved orthogonal ribosomes
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United States of America Patent
Stats
-
Jul 30, 2013
Grant Date -
Apr 29, 2010
app pub date -
Nov 28, 2007
filing date -
Nov 30, 2006
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
There is provided a method for evolving an orthogonal rRNA molecule, comprising the steps of: providing one or more libraries of mutant orthogonal rRNA molecules and introducing the libraries into cells such that the orthogonal rRNA is incorporated into ribosomes to provide orthogonal ribosomes; providing one or more orthogonal mRNA molecules which (i) are not translated by natural ribosomes, and (ii) comprise one or more orthogonal mRNA codons; assaying the translation of the orthogonal mRNA and selecting the orthogonal rRNA molecules which translate the orthogonal mRNA, wherein the assay in step (c) requires translation of one or more orthogonal mRNA codons in the orthogonal mRNA; and orthogonal ribosomes incorporating such rRNA molecules.
First Claim
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International Classification(s)
- 2007 Application Filing Year
- C07H Class
- 2326 Applications Filed
- 871 Patents Issued To-Date
- 37.45 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jan 30, 2025 |
