Method of measuring enzymatic activity of adsorbed allergenic enzyme
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United States of America Patent
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Jul 23, 2013
Grant Date -
Oct 15, 2009
app pub date -
Nov 23, 2006
filing date -
Nov 24, 2005
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Abstract
The invention relates to a method of measuring the immunological activity of a vaccine preparation in the form of a mixture of one or more allergenic enzyme(s) and an oxygen-containing metal salt adjuvant, wherein the mixture comprises a liquid phase and a solid phase, and wherein at least a part of the allergenic enzyme(s) is adsorbed to the solid phase, the method comprising the steps of measuring the enzymatic activity of the mixture in an enzyme activity assay, and using the measurement obtained as an indication of the immunological activity of the vaccine preparation, or using the measurement obtained for quantifying the amount of allergenic enzyme.
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