Identification of co-regulation patterns by unsupervised cluster analysis of gene expression data

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United States of America Patent

PATENT NO 8489531
APP PUB NO 20110125683A1
SERIAL NO

13019585

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Abstract

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A method is provided for unsupervised clustering of gene expression data to identify co-regulation patterns. A clustering algorithm randomly divides the data into k different subsets and measures the similarity between pairs of datapoints within the subsets, assigning a score to the pairs based on similarity, with the greatest similarity giving the highest correlation score. A distribution of the scores is plotted for each k. The highest value of k that has a distribution that remains concentrated near the highest correlation score corresponds to the number of co-regulation patterns.

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Patent OwnerAddress
HEALTH DISCOVERY CORPORATION4243 DUNWOODY CLUB DRIVE SUITE 202 ATLANTA GA 30350

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ben, Hur Asa Seattle, US 2 12
Elisseeff, Andre Thalwil, CH 20 566
Guyon, Isabelle Berkeley, US 147 3536

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