Model animal in which state of disease condition is observable in real time, gene construct for achieving the same and use of the same
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United States of America Patent
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Jul 16, 2013
Grant Date -
Oct 28, 2010
app pub date -
Mar 10, 2006
filing date -
Mar 11, 2005
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Abstract
Provided is a technique for observing in real time the state of a disease condition in a tissue of an animal or the state of a functionally adverse condition which is a prelude to the disease condition without injuring the animal. This can be achieved by the use of a gene construct having a reporter gene integrated under the control of a hypoxia responsible promoter an ODD domain (oxygen dependent degradation domain) integrated upstream to the reporter gene.
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