Botulinum neurotoxin a protein receptor and uses thereof
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United States of America Patent
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Jul 2, 2013
Grant Date -
Oct 8, 2009
app pub date -
Oct 30, 2006
filing date -
Oct 28, 2005
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Abstract
The invention relates to an isolated polypeptide of the luminal domain of synaptic vesicle glycoprotein 2C of Homo sapiens wherein at least 70 percent of the amino acid sequence is identical to the amino acid sequence of the SV2C of Homo sapiens. The polypeptide binds the HC fragment of botulinum neurotoxin A provided that the polypeptide is not the synaptic vesicle glycoprotein 2C of Homo sapiens.
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