Sitagliptin intermediates, preparation methods and uses thereof
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United States of America Patent
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Jun 25, 2013
Grant Date -
Jul 12, 2012
app pub date -
Sep 25, 2010
filing date -
Sep 27, 2009
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Abstract
The present invention relates to Sitagliptin intermediate and preparation method and use thereof. The method comprises reacting compound of formula (II) and trifluorobromobenzene with a Grignard reagent by a Grignard reaction to obtain a compound of formula (I). Compound of formula (I) is a new intermediate compound for the synthesis of Sitagliptin. Compound of formula (I) can be easily used for preparing another important intermediate compound of formula (V) for the synthesis of Sitagliptin. The structures of the compounds mentioned above are as the following:
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