Hybrid-ionone and curcumin molecules as anticancer agents
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United States of America Patent
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Jun 25, 2013
Grant Date -
Sep 22, 2011
app pub date -
Nov 25, 2009
filing date -
Nov 26, 2008
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Abstract
The present invention relates to the synthesis of a series of ionone and curcumin derivatives as multi-targeting agents effective against both hormone-sensitive and hormone-independent cancers. In particular, the present invention is directed to a distinct class of bifunctional antiandrogens, which inhibit both AR and IKBkinases (IKK). A series of ionone-based chalcones were synthesized and their in vitro cytotoxicity against prostate cancer cell lines were demonstrated. A series of derivatives formed by reacting ionone-based chalcones and hydrazines demonstrate substantial antiproliferative activities in prostate cancer, breast cancer and lung cancer cell lines.
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