Saturated bicyclic heterocyclic derivatives as SMO antagonists
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United States of America Patent
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Jun 25, 2013
Grant Date -
Jul 28, 2011
app pub date -
Aug 28, 2009
filing date -
Aug 29, 2008
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Abstract
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
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