Method of treating amykloidosis comprising administering an anti-HMGB-1 antibody
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United States of America Patent
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Jan 15, 2013
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Sep 22, 2011
app pub date -
Feb 15, 2008
filing date -
Feb 15, 2007
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Abstract
Previously, it was difficult to obtain high-affinity antibodies that specifically bind to HMGB-1 but not to HMGB-2. Under this circumstance, the present inventors successfully obtained antibodies that are more reactive to HMGB-1 than to HMGB-2 by using specific peptides as an antigen. The present inventors also demonstrated that the antibodies had a HMGB-1-neutralizing activity. The present inventors administered the antibodies to amyloidosis model animals, and as a result, successfully demonstrated that the antibodies produced a significant therapeutic effect.
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