Neural progenitor cells derived from embryonic stem cells

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United States of America Patent

PATENT NO 8460931
SERIAL NO

13361976

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Abstract

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The present invention relates to undifferentiated human embryonic stem cells, methods of cultivation and propagation and production of differentiated cells. In particular it relates to the production of human ES cells capable of yielding somatic differentiated cells in vitro, as well as committed progenitor cells such as neural progenitor cells capable of giving rise to mature somatic cells including neural cells and/or glial cells and uses thereof. This invention provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and cells that are generated along the pathway of neural differentiation may be used for: the study of the cellular and molecular biology of human neural development, discovery of genes, growth factors, and differentiation factors that play a role in neural differentiation and regeneration, drug discovery and the development of screening assays for teratogenic, toxic and neuroprotective effects.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL UNIVERSITY OF SINGAPORESINGAPORE SINGAPORE SINGAPORE CITY SINGAPORE
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT COMPANY LTDP O BOX 1200 JERUSALEM 91120
MONASH UNIVERSITYMANAGER INTELLECTUAL PROPERTY INDUSTRY ENGAGEMENT & COMMERCIALISATION BUILDING 75 CLAYTON CAMPUS VICTORIA 3180

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ben-Hur, Tamir Jerusalem, IL 12 192
Pera, Martin Federick Los Angeles, US 2 2
Reubinoff, Benjamin Eithan Moshav Bar-Giora, IL 30 366

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