Rapamycin carbonic ester analogues, pharmaceutical compositions, preparations and uses thereof
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United States of America Patent
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Jun 4, 2013
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Jul 7, 2011
app pub date -
Sep 17, 2009
filing date -
Sep 18, 2008
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Abstract
Rapalogs of formula I, pharmaceutically acceptable salts, pharmaceutical compositions, and preparation methods and uses thereof. The rapalogs have the structure of formula I and can be used as an anti-tumor medicament. Comparing with rapamycin, the rapalogs of the present invention exhibit enhanced water solubility, and improved pharmacological and pharmacokinetic properties by introducing a hydrophilic and polar group such as a hydroxyl.
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