Modified therapeutic agents
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United States of America Patent
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Jun 4, 2013
Grant Date -
Apr 14, 2011
app pub date -
Jan 15, 2010
filing date -
Sep 5, 2002
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Abstract
The invention provides a modified therapeutic agent, said modified agent comprising three or more membrane binding elements with low membrane affinity covalently associated with the agent which elements are capable of interacting independently and with thermodynamic additivity, with components of cellular or artificial membranes exposed to extracellular fluids wherein at least two membrane binding elements are lipophilic elements, which may be aliphatic acyl groups, which may be selected from the list consisting of Myristoyl, Decanoyl or Hexanoyl.
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