Derivatives of squaric acid with anti-proliferative activity
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United States of America Patent
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May 28, 2013
Grant Date -
Aug 21, 2008
app pub date -
Feb 21, 2007
filing date -
Feb 21, 2007
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Abstract
The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers and isomers thereof, as a single stereoisomer or a mixture of stereoisomers, or as a pharmaceutically acceptable salt thereof. These compounds show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
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