Chemo-enzymatic peptide synthesis via C-terminal ester interconversion

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United States of America Patent

PATENT NO 8450084
APP PUB NO 20100311113A1
SERIAL NO

12682653

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Abstract

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The invention relates to a method for preparing an optionally N-protected amino acid C-terminal ester or an optionally N-protected peptide C-terminal ester, comprising transesterifying the C-terminal t-alkyl ester of the amino acid or the C-terminal t-alkyl ester of the peptide with an alcohol (other than the t-alcohol corresponding to the t-alkyl group of the ester) in the presence of a hydrolytic enzyme (E.C. 3).

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Patent Owner(s)

Patent OwnerAddress
FRESENIUS KABI IPSUM S R LVIA ROMA 108 CASSINA DE' PECCHI - MILANO 20060

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cusan, Claudia Aachen, DE 6 0
Moody, Harold Monro Gulpen, NL 14 41
Nuijens, Timo Maastricht, NL 11 14
Quaedflieg, Peter Jan Leonard Mario Elsloo, NL 24 33
Van, Dooren Theodorus Johannes Godfried Maria Roermond, NL 4 33

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