Radiofluorinated compounds and their preparation
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United States of America Patent
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May 21, 2013
Grant Date -
Jul 5, 2012
app pub date -
Mar 8, 2012
filing date -
Apr 20, 2006
priority date (Note) -
Expired
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Abstract
The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.
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