Catalyzed carbonylation in the synthesis of angiotensin II antagonists
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United States of America Patent
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May 21, 2013
Grant Date -
Apr 28, 2011
app pub date -
Mar 19, 2009
filing date -
Mar 20, 2008
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Expired
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Abstract
One embodiment disclosed in the invention is the efficient synthesis of halogenated biaryl starting material via Grignard chemistry and the use thereof. Another embodiment of the invention is the reaction of catalyzed carbonylation of the 3′-(2′-halo-biphenyl-4-ylmethyl)-1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′]bibenzoimidazolyl (TLMH) using either gaseous carbon monoxide in a solvent mixture containing water; or formic acid salts optionally together with acetic acid in anhydrous solvent.
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