Preparation of micro-porous crystals and conjugates thereof
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United States of America Patent
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May 21, 2013
Grant Date -
Nov 24, 2011
app pub date -
May 3, 2011
filing date -
Nov 2, 2006
priority date (Note) -
Expired
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Abstract
A conjugate comprising a dye-labeled microporous crystal, a stop-cock moiety, and covalently bound thereto an affinity binding agent is disclosed. The dye-labeled microporous crystal is a zeolite crystal, such as a zeolite L crystal, having a large number of channels in its interior into which the dye is loaded. The stop-cock moiety can be functionalized with an amino group to which a carboxyester group can be attached. The affinity binding agent allows for the binding to a biological moiety. The conjugate of the moiety can be used in in-vivo and/or in-vitro imaging applications.
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