Compositions and methods for treating ocular diseases and conditions
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United States of America Patent
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May 21, 2013
Grant Date -
Sep 9, 2010
app pub date -
Oct 26, 2007
filing date -
Oct 27, 2006
priority date (Note) -
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Abstract
The present invention relates to compositions and methods for prevention and treatment of diseases and conditions, particularly ocular diseases and conditions, characterized by aberrant fibrogenesis or scarring, inflammation, and/or aberrant neovascularization or angiogenesis. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against the bioactive lipid, sphingosine-1-phosphate, and its variants, which moieties are capable of decreasing the effective concentration of bioactive lipid being targeted. In one embodiment, the immune-derived moiety is a humanized monoclonal antibody that is reactive against sphingosine-1-phosphate.
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