Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use
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United States of America Patent
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May 14, 2013
Grant Date -
Sep 30, 2010
app pub date -
Mar 24, 2010
filing date -
Mar 24, 2009
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Expired
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Abstract
The invention provides compounds, compositions and methods to treat certain inflammatory conditions and/or oncology by administering a compound that inhibits PI3K isoforms, particularly the delta isoform. It further provides specific stereoisomers of a compound useful for these methods. In particular, the compound is an optically active atropisomer of 2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one.
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