Inhibitors of beta-lactamase
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United States of America Patent
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May 14, 2013
Grant Date -
Nov 4, 2010
app pub date -
May 21, 2007
filing date -
May 22, 2006
priority date (Note) -
Expired
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Abstract
This invention provides novel β-lactamase inhibitors of the aryl- and heteroaryl-sulfonamidomethylphosphonate monoester class having nitrogen-based cations or quarternary ammomium groups. The compounds inhibit three classes of β-lactamases and synergize the antibacterial effects of β-lactam antibiotics (e.g., imipenem and ceftazimdime) against those micro-organisms normally resistant to the β-lactam antibiotics as a result of the presence of the β-lactamases.
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